In the fascinating world of stroke rehabilitation, the constant evolution of scientific methodologies and technologies is leading to significant advancements in the quality of life for patients. The capacity to build upon the fundamental understanding of neuroplasticity, the brain's ability to reorganize itself by forming new neural connections, is revolutionizing the realm of stroke rehab centers, prompting us to explore the emerging trends and predictions in this field.

The past decade has seen a vivid surge in the development and application of non-invasive brain stimulation (NIBS) techniques, such as Transcranial Magnetic Stimulation (TMS) and transcranial Direct Current Stimulation (tDCS). These techniques are premised on modulating neural activity in specific regions of the brain to stimulate recovery after stroke. TMS, for example, uses a magnetic field to induce an electrical current in the brain, thus stimulating neural activity. Conversely, tDCS applies a low-intensity, continuous electrical current to the scalp, altering the neuronal membrane potential and modulating neuronal excitability.

While these techniques show promise, it is pivotal to recognize some inherent constraints. For instance, the effects of TMS and tDCS can be transient and often require repeated sessions for sustained improvement. Additionally, the heterogeneity in stroke pathology presents a challenge to the universal applicability of these techniques. Therefore, a deeper understanding of individual patients’ pathophysiological processes post-stroke is essential for tailoring personalized therapeutic strategies.

The rising interest in harnessing the power of virtual reality (VR) in stroke rehabilitation is another trend worth noting. VR can deliver an immersive and interactive therapy experience, allowing patients to engage in repetitive task practice, an integral component of motor learning post-stroke. Moreover, with haptic feedback – a technology that recreates the sense of touch – patients can receive real-time feedback on their movement performance, thereby refining their motor skills.

However, the utility of VR is not just confined to motor recovery. Cognitive rehabilitation, crucial for tasks like memory recall and problem-solving, has also found a valuable ally in VR. By creating simulated environments, VR allows for cognitive training in a controlled yet realistic setting. The trade-off here is the challenge in creating truly individualized VR experiences and the initial high costs of setting up these systems.

Artificial Intelligence (AI) is another powerful tool shaping the future of stroke rehabilitation. Machine learning algorithms can help predict patient outcomes, inform treatment strategy, and monitor progress. For instance, predictive modelling can identify patterns in a patient’s recovery trajectory, which can be used to optimize their individual therapy plan. Moreover, AI can aid in patient monitoring, evaluating their engagement and performance in therapy. However, the successful deployment of AI in stroke rehabilitation necessitates rich, quality data and strong computational capabilities.

The future of stroke rehab centers is threading towards precision medicine – tailoring treatment strategies to individual patients based on their unique characteristics and responses. This approach resonates with the concept of neurodiversity, recognizing and respecting neurological differences as a natural human variation. Hence, the successful implementation of such an approach would require a paradigm shift in the traditional uniform treatment methodologies, towards a more personalized and holistic approach.

The advent of advanced technologies like NIBS, VR, and AI is transforming the landscape of stroke rehabilitation. However, the intricate interplay between the individual, their environment, and the rehabilitation process underscores the need for an integrative approach. It is thus crucial to continually refine these technologies, alongside traditional therapeutic approaches, to ensure they are delivering on their promises of improved patient outcomes.

In conclusion, the future of stroke rehab centers is set to be an intriguing amalgamation of technology and personalized care, underpinned by a profound understanding of neuroplasticity and neurodiversity. The dynamic interplay of these elements will undoubtedly influence the future trajectories of stroke rehabilitation, presenting both unique challenges and exciting opportunities.